---
title: "Risk Aversion Analysis"
output: rmarkdown::html_vignette
vignette: >
  %\VignetteIndexEntry{Risk Aversion Analysis}
  %\VignetteEncoding{UTF-8}
  %\VignetteEngine{knitr::rmarkdown}
editor_options: 
  chunk_output_type: console
---
  
```{r, include = FALSE}
knitr::opts_chunk$set(
collapse = TRUE,
comment = "#>",
fig.width = 6
)
```

```{r setup, results='hide', message=FALSE, warning=FALSE, echo=FALSE}
library(BCEA)
library(dplyr)
library(reshape2)
library(ggplot2)
library(purrr)
```

Set-up analysis using smoking cessation data set.

```{r}
data(Smoking)

treats <- c("No intervention", "Self-help", "Individual counselling", "Group counselling")
bcea_smoke <- bcea(eff, cost, ref = 4, interventions = treats, Kmax = 500)
```

Run the risk aversion analysis straight away
with both the base R and ggplot2 versions of plots.

```{r}
r <- c(0, 0.005, 0.020, 0.035)
CEriskav(bcea_smoke) <- r

plot(bcea_smoke)
plot(bcea_smoke, graph = "ggplot")
```

Notice that the first value is asymptotically zero but the function handles that for us.
Previously, you had to use something like 1e-10 which was a bit awkward.

Now we modify the comparison group so that it doesn't contain 2 ("self-help") anymore.
We still keep the same first comparison though "no intervention".

```{r}
setComparisons(bcea_smoke) <- c(1,3)
```

If we rerun the analysis we should see that the output is exactly the same.

```{r}
CEriskav(bcea_smoke) <- r

plot(bcea_smoke)
plot(bcea_smoke, graph = "ggplot")
```

What happens when we only have one risk adjustment value?
Set it to zero so this should be exactly the same as the baseline `bcea` case.

```{r}
r <- 0
CEriskav(bcea_smoke) <- r

plot(bcea_smoke)

plot(bcea_smoke, graph = "ggplot")

bcea_smoke0 <- bcea(eff, cost, ref = 4, interventions = treats, Kmax = 500)
eib.plot(bcea_smoke0, comparison = 1)
evi.plot(bcea_smoke0)
```

Check that unusual or meaningless values for `r` are handled gracefully.
At present the are just calculated and plotting exactly the same way.
_should we limit values?_

```{r}
# negative
r <- -0.005
CEriskav(bcea_smoke) <- r
plot(bcea_smoke)

# large
r <- 2
CEriskav(bcea_smoke) <- r
plot(bcea_smoke)
```

If we select a new set of comparison interventions what will happen?
There are specified in a different order and for other plots this makes very little difference (perhaps changing the line types).
However, it is different for `CEriskav()` because only the first comparison intervention is plotted so changing the order changes the plot.
We can see this by swapping "non intervention" and "individual counselling" interventions from the analysis above.

```{r}
setComparisons(bcea_smoke) <- c(3,1)
```

```{r}
r <- c(0, 0.005, 0.020, 0.035)
CEriskav(bcea_smoke) <- r

plot(bcea_smoke)
plot(bcea_smoke, graph = "ggplot")
```

The previous version of `CEriskav()` had a `comparison` argument where you could specify the single intervention to plot and if this wasn't set then it defaulted to the first.
It seems neater to separate the definition of the analysis with the plotting so now if you did want to specify a different comparison intervention when using `CEriskav()` then you would have to use `setComparison()` first and then call the plotting function.

Check legend position argument:

```{r}
# base R
plot(bcea_smoke, pos = c(1,0))
plot(bcea_smoke, pos = c(1,1))

plot(bcea_smoke, pos = TRUE)
plot(bcea_smoke, pos = FALSE)

plot(bcea_smoke, pos = "topleft")
plot(bcea_smoke, pos = "topright")
plot(bcea_smoke, pos = "bottomleft")
plot(bcea_smoke, pos = "bottomright")

# ggplot2
plot(bcea_smoke, graph = "ggplot", pos = c(1,0))
plot(bcea_smoke, graph = "ggplot", pos = c(1,1))

plot(bcea_smoke, graph = "ggplot", pos = TRUE)
plot(bcea_smoke, graph = "ggplot", pos = FALSE)

plot(bcea_smoke, graph = "ggplot", pos = "top")
plot(bcea_smoke, graph = "ggplot", pos = "bottom")
plot(bcea_smoke, graph = "ggplot", pos = "left")
plot(bcea_smoke, graph = "ggplot", pos = "right")
```


```{r eval=FALSE, echo=FALSE}
# create output docs
rmarkdown::render(input = "vignettes/ceac.Rmd", output_format = "pdf_document", output_dir = "vignettes")
rmarkdown::render(input = "vignettes/ceac.Rmd", output_format = "html_document", output_dir = "vignettes")
```